2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide

SKU: orb1305992

Description

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	1258292-64-6
MW	350.2
Purity	99.65%
Formula	C₁₆H₁₃Cl₂N₃O₂
SMILES	Clc1cccc(Cl)c1C(=O)Nc1ccnc(NC(=O)C2CC2)c1
Target	JAK
Solubility	DMSO:3.51 mg/mL (10.02 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.86 mM)

Bioactivity

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Target IC50	JAK3:0.4 nM (Ki)\|TYK2:4.8 nM (Ki)\|JAK1:0.7 nM (Ki)\|JAK2:0.7 nM (Ki)

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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diseases, 2,6 Dichloro N (2 (cyclopropanecarboxamido)pyridin 4 yl)benzamide, 2,6DichloroN(2(cyclopropanecarboxamido)pyridin4yl)benzamide, bowel, Inhibitor, GDC 046, GDC046, GDC-046, IBD, inhibit, IL-23, IL-12, JAK, JAK1, JAK2, Janus kinase, JAK3, inflammatory, TYK2

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Compound Identifiers

PubChem CID

49839561 ↗

Key Properties

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No computed properties available.

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