3-Bromopyruvic acid

SKU: orb1220657

Description

3-Bromopyruvic acid is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.

Images & Validation

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Key Properties

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CAS Number	1113-59-3
MW	166.96
Purity	>98% (HPLC)
Formula	C₃H₃BrO₃
SMILES	OC(=O)C(=O)CBr
Target	hexokinase II
Solubility	H2O:32 mg/mL (191.66 mM)

Bioactivity

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In Vivo	Animal model: Female nude mice (BALB/c; 4-5-weeks old and 18-20 g). Dosage: 8 mg/kg. Administration: i.p.; every 4 days for 28 days. Result: Showed antitumor efficacy in tumor xenografts. Read more...
In Vitro	Cell Viability Assay Cell line: MCF-7 and MDA-MB-231 cells. Concentration: 40, 80, 160 or 320 μM. Incubation time: 24 hours. Result: 3-Bromopyruvate (80 and 160 μmol/l) and TRAIL (400 ng/ml) significantly inhibited cell viability. Read more...

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Bromopyruvic acid | Hexokinase II Inhibitor II 3-BP

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Gene Symbol

hexokinase II

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