5-O-Caffeoylshikimic acid

SKU: orb1297486

Description

Research Area

Cell Biology, Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	73263-62-4
MW	336.29
Purity	98.35%
Formula	C₁₆H₁₆O₈
SMILES	O[C@@H]1C=C(C[C@@H](OC(=O)\C=C\c2ccc(O)c(O)c2)[C@@H]1O)C(O)=O
Target	IL Receptor,TNF,NO Synthase
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.95 mM);DMSO:50 mg/mL (148.68 mM);H2O:20 mg/mL (59.47 mM)

Bioactivity

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Target IC50

XOD:13.96 μM

In Vitro

Cytotoxic activity of saponins and phenolic compounds have been described in the literature, but no reports were found on their multidrug resistance (MDR)-modulating effects on human mdr1 gene-transfected mouse lymphoma cell line.Methylprototribestin, structurally related compounds and a mixture of 3 acetylated isomers of methylprotodioscin were investigated for ant Proliferative effect and modulation of drug accumulation. Results the growth inhibitory dose (ID50) o the compounds ranged from 12.64 to 20.62 mug/ml. Methylprototribestin wa the most effective resistance modifier. however, methylprotodioscin, pseudoprotodioscin, prosapogenin A of dioscin, tribestin and 5-O-Caffeoylshikimic acid showed moderate MDR reversal activity. In a checkerboard method, methyloprototribestin an the mixture o the 3 acetylated isomers enhance the ant Proliferative effects on MDR cells in combination with doxorubicin. CONCLUSION: Based on these results, methylprototribestin an the mixture o the 3 acetylated isomers can be recommended for further in vivo experiments in combination with anthracyclines in human MDR-cancer xenograft transplanted mice

Storage & Handling

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Storage	keep away from direct sunlight,store at low temperature,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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TNF-α, 5 O Caffeoylshikimic acid, 5OCaffeoylshikimic acid, 5-O-Caffeoylshikimic acid, Inhibitor, IL Receptor, ILReceptor, inhibit, NOSynthase, NO Synthase

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Compound Identifiers

PubChem CID

5281762 ↗

Key Properties

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No computed properties available.

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