9-cis-Retinoic Acid

SKU: orb1987229

Description

9-cis-Retinoic Acid (Alitretinoin) is a vitamin A-derived pan-agonist of RAR and RXR receptors. It exhibits anticancer and anti-inflammatory properties by inducing apoptosis and cell cycle arrest, making it a valuable tool for in vitro and in vivo studies of advanced tumors and neuroprotection.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	5300-03-8
MW	300.44
Purity	99.34%
Formula	C₂₀H₂₈O₂
SMILES	C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O
Target	Apoptosis
Solubility	DMSO:15 mg/mL (49.93 mM)

Bioactivity

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In Vivo	In male C57BL/6J mice (6-8 weeks old; 19-22 g), following bile duct ligation, treatment with 9-cis-Retinoic Acid (1 mg/kg; intravenous injection; once daily; for 10 days) significantly decreased serum ALT and AST levels and alleviated hepatic necrosis. Read more...
In Vitro	In CA 9-22 and NA cells, 9-cis-Retinoic acid (1 μM, 10 μM; 0 day, 1 day, 3 days, 5 days) significantly decreased proliferation.

Storage & Handling

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Storage	keep away from direct sunlight,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Apoptosis, 9cisRetinoic Acid, 9 cis Retinoic Acid, 9-cis-Retinoic Acid, Alitretinoin

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Compound Identifiers

PubChem CID

449171 ↗

Key Properties

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No computed properties available.

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