Ac2-26

SKU: orb1984040

Description

Ac2-26, an annexin A1 mimetic peptide, was able to attenuate renal inflammatory injury in a diabetic mouse model through inhibition of p38MAPK/NF-κB, as well as sepsis-induced cardiomyocyte apoptosis through the LXA4/PI3K/AKT signalling pathway, and hepatic ischaemia-reperfusion injury in mice by modulating IL-22/IL-22R1/STAT3 signalling pathway.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	151988-33-9
MW	3089.43
Purity	98.78%
Formula	C₁₄₁H₂₁₀N₃₂O₄₄S
SMILES	C([C@@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CC=C(O)C=C2)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)C(C)C)=O)[C@@H](C)O)=O)CCC(N)=O)=O)[C@@H](C)C)=O)=O)CCC(O)=O)=O)CCC(N)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)CC(N)=O)=O)CCC(O)=O)=O)[C@H](CC)C)=O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=CC=C3)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)C)=O)CCSC)=O)[C@@H](C)C)=O)CO)=O)CCC(O)=O)=O)=O)CC(C)C)=O)CCCCN)=O)CCC(N)=O)=O)C)=O)C=4C=5C(NC4)=CC=CC5
Target	Annexin A,PI3K,Akt,NF-κB,p38 MAPK,IL Receptor,STAT
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (0.65 mM);H2O:5 mg/mL (1.62 mM)

Bioactivity

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In Vivo

In mice subjected to ischemia-reperfusion injury, Ac2-26 (1 mg/kg, i.v., just before reperfusion) reduced myocardial necrosis, inflammation (48 h), and cardiac fibrosis/apoptosis (7 days). In myocardial infarction models, continuous subcutaneous delivery of Ac2-26 (1 mg/kg/day, via osmotic pump for 1 week) delayed early cardiac dysfunction at 1 week, though no additional benefit was observed at 4 weeks.

Storage & Handling

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Storage	keep away from moisture \| store at -20°C \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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Ac2 26, Ac226, Ac-2-26, Ac2-26

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Compound Identifiers

PubChem CID

16138723 ↗

Key Properties

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No computed properties available.

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Ac2-26 (orb1984040)

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Purity:	> 95% by hplc
MW:	3089.46 Da
Structure:	Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys-OH

Applications:	IHC-P
Reactivity:	Human
Species/Host:	Rabbit
Clonality:	Monoclonal
Conjugation:	Unconjugated

MW:	3203.45
Formula:	C₁₄₃H₂₁₁F₃N₃₂O₄₆S

Ac2-26

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Ac2-26 (orb1984040)

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