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ACBI1

SKU: orb1218328

Description

ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis.

Images & Validation

Key Properties

CAS Number2375564-55-7
MW936.1
Purity>98% (HPLC)
FormulaC49H58FN9O7S
SMILESCC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@H](C(C)(C)C)NC(C4(CC4)F)=O)=O)=O)C(OCCOC5=CC=C(CN6CCN(C7=CC(C8=C(O)C=CC=C8)=NN=C7N)CC6)C=C5)=C2
TargetApoptosis
SolubilityDMSO:100 mg/mL (106.83 mM)

Bioactivity

In Vitro
ACBI1 (1-10000 nM; 3-7 days) shows anti-proliferative activity. ACBI1 (0.3 μM; 100 h) induces apoptosis in SK-MEL-5 cells. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase von Hippel-Lindau. Cell Proliferation Assay Cell line: MV-4-11, NCI-H1568 cells. Concentration: 0-1000 nM. Incubation time: 3-7 days. Result: Showed anti-proliferative activity with IC50 of 29, 68 nM for MV-4-11, NCI-H1568 cells, respectively. Apoptosis Analysis Cell line: SK-MEL-5 cells. Concentration: 0.3 μM Incubation time: 100 h. Result: Induced apoptosis in SK-MEL-5 cells.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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ACBI1 (orb1218328)

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200 mg
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5 mg
¥ 4,420.00
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¥ 6,760.00
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¥ 11,050.00
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¥ 15,600.00
100 mg
¥ 20,800.00