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ACBI1

SKU: orb1307575

Description

ACBI1 is a potent VHL-based PROTAC that selectively degrades SMARCA2, SMARCA4, and PBRM1 with low nanomolar DC50 values. It demonstrates anti-proliferative and pro-apoptotic activity in cellular models like MV-4-11, making it a valuable chemical probe for studying chromatin remodeling and oncology research.

Research Area

Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2375564-55-7
MW936.1
Purity98.15% (May vary between batches)
FormulaC49H58FN9O7S
SMILESNC1=C(C=C(N=N1)C2=C(O)C=CC=C2)N3CCN(CC4=CC=C(OCCOC5=C(CNC(=O)[C@H]6N(C([C@@H](NC(=O)C7(F)CC7)C(C)(C)C)=O)C[C@H](O)C6)C=CC(=C5)C8=C(C)N=CS8)C=C4)CC3
TargetEpigenetic Reader Domain,PROTACs,Apoptosis
SolubilityDMSO:100 mg/mL (106.83 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (4.27 mM)

Bioactivity

Target IC50
PBRM1:32 nM (DC50)|SMARCA2:6 nM (DC50)|SMARCA4:11 nM (DC50)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

inhibit, Inhibitor, DC50: 6 nM (SMARCA2), 11 nM (SMARCA4), 32 nM (PBRM1), EpigeneticReaderDomain, Epigenetic Reader Domain, anti-proliferative, Apoptosis, ACBI 1, ACBI1, ACBI-1, PROTAC, PROTACs

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

ACBI1 (orb1307575)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,820.00
5 mg
¥ 3,640.00
10 mg
¥ 5,590.00
25 mg
¥ 8,840.00
50 mg
¥ 12,480.00
100 mg
¥ 16,510.00
DispatchUsually dispatched within 3-5 working days
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