Agomelatine hydrochloride

SKU: orb1689501

Description

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	1176316-99-6
MW	279.76
Purity	99.57%
Formula	C₁₅H₁₈ClNO₂
SMILES	Cl.COc1ccc2cccc(CCNC(C)=O)c2c1
Target	Melatonin Receptor,Endogenous Metabolite,5-HT Receptor,MT Receptor
Solubility	H2O:0.1 mg/mL (0.36 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (11.8 mM);DMSO:90 mg/mL (321.7 mM)

Bioactivity

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Target IC50	MT2 (human):0.12 (Ki, CHO Cells)\|MT2 (human):0.27 (Ki, HEK Cells)\|MT1 (human):0.1 (Ki, CHO Cells)\|MT1 (human):0.06 (Ki, HEK Cells)\|5-HT2C receptor:6.2 (pKi, human)\|5-HT2C receptor:6.4 (pKi, native porcine) Read more...
In Vivo	Agomelatine (25, 50, or 75 mg/kg; i.p.) exhibits antioxidant activity in Strychnine (75 mg/kg, i.p.) or Pilocarpine (400 mg/kg, i.p.) induced seizure models in mice, but does not affect oxidative stress parameters in Pentylenetetrazole (PTZ) or Picrotoxin (PTX) induced seizure models compared to controls. Read more...
In Vitro	Agomelatine (S 20098) functions as a full agonist for the MT1 and MT2 receptors, exhibiting EC50 values of 1.6±0.4 and 0.10±0.04 nM, respectively, when expressed in CHO or HEK cell membranes. Additionally, Agomelatine interacts with h5-HT2B receptors, displaying a marked preference (6.6). However, it demonstrates low affinity for both native and cloned human 5-HT2A receptors, with values just below 5.0/5.3, and similarly low affinity for 5-HT1A receptors (below 5.0/5.2), while exhibiting negligible affinity for other 5-HT receptors. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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MT2 receptor, MT Receptor, MT1 receptor, MTReceptor, Agomelatine Hydrochloride, S 20098 Hydrochloride, S20098 Hydrochloride, S-20098 Hydrochloride, S-20098 hydrochloride

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Compound Identifiers

PubChem CID

66980040 ↗

Key Properties

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No computed properties available.

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