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AL 8697

SKU: orb1310012

Description

AL 8697 is a potent and selective p38α MAPK inhibitor, exhibiting significant selectivity over p38β and a broad kinase panel. Its anti-inflammatory properties support its use in research models investigating inflammatory pathways, both in cellular assays and in vivo studies.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number1057394-06-5
MW402.41
Purity98.96% (May vary between batches)
FormulaC21H21F3N4O
SMILESCc1c(F)cc(cc1-c1c(F)cn2c(nnc2c1F)C(C)(C)C)C(=O)NC1CC1
Targetp38 MAPK,Autophagy
SolubilityDMSO:95 mg/mL (236.08 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (8.2 mM)

Bioactivity

Target IC50
p38β:82 nM|p38α:6 nM
In Vivo
In male Wistar rats, AL 8697 (1, 3, 10, 30 mg/kg; p.o.) decreases the oedema in right and left paws in a dose-dependent manner thereby causing a larger improvement in the contralateral un-injected paw.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

AL8697, AL-8697, AL 8697, Autophagy, inhibit, p38MAPK, p38α, p38β, p38 MAPK, Inhibitor

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  • AL 8697 [orb1940830]

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    1057394-06-5

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    C21H21F3N4O

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 80.00
5 mg
$ 130.00
1 ml x 10 mM (in DMSO)
$ 150.00
10 mg
$ 170.00
25 mg
$ 260.00
50 mg
$ 360.00
100 mg
$ 470.00
DispatchUsually dispatched within 3-5 working days
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