Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

AL 8697

SKU: orb1940830

Description

AL 8697 is a selective p38α MAPK inhibitor (IC50 = 6 nM) with 14-fold selectivity over p38β (IC50 = 82 nM) and 300-fold selectivity over a panel of 91 kinases. AL 8697 has anti-inflammatory activity.(In Vivo):In male Wistar rats, AL 8697 (1, 3, 10, 30 mg/kg; p.o.) decreases the oedema in right and left paws in a dose-dependent manner thereby causing a larger improvement in the contralateral un-injected paw.

Images & Validation

Key Properties

CAS Number1057394-06-5
MW402.421
Purity>98% (HPLC)
FormulaC21H21F3N4O
SMILESCc1c(F)cc(cc1-c1c(F)cn2c(nnc2c1F)C(C)(C)C)C(=O)NC1CC1
Targetp38 MAPK
SolubilityIn Vitro: DMSO : 100 mg/mL (248.50 mM)

Bioactivity

In Vivo
AL 8697 (1-30 mg/kg; p.o. ; once daily for 10 days) dose-dependently decreases the oedema in right and left paws. Animal model: Male Wistar rats. Dosage: 1, 3, 10, 30 mg/kg. Administration: Oral gavage; once daily for 10 days. Result: Dose-dependently decreased the oedema in right and left paws, causing a larger improvement in the contralateral un-injected paw.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Similar Products

  • AL 8697 [orb1310012]

    98.96% (May vary between batches)

    1057394-06-5

    402.41

    C21H21F3N4O

    50 mg, 100 mg, 1 mg, 5 mg, 10 mg, 25 mg, 1 ml x 10 mM (in DMSO)
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Protocol Information

Available Sizes

Select a size below

5 mg
$ 400.00
10 mg
$ 570.00
25 mg
$ 950.00
50 mg
$ 1,340.00
100 mg
$ 1,830.00
500 mg
$ 3,660.00