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AMN 082 dihydrochloride

SKU: orb1217420

Description

AMN 082 dihydrochloride is a selective metabotropic glutamate mGlu7 receptor agonist reported to exhibit antidepressant activity.

Research Area

Stem Cell & Developmental Biology

Images & Validation

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AMN 082 dihydrochloride

Key Properties

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CAS Number97075-46-2
MW465.46
Purity>98% (HPLC)
FormulaC28H30Cl2N2
SMILES[H]Cl.[H]Cl.C(NCCNC(C1=CC=CC=C1)C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4
TargetGluR
SolubilityIn Vitro: DMSO : 33.33 mg/mL (71.61 mM)

Bioactivity

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In Vivo
AMN082 (6 mg/kg; p.o.) induces stress hormone increases in an mGluR7-dependent fashion in mGluR7+/+ mice (C57BL/6 genetic background). AMN082 (1.25-5.0 mg/kg, i.p.; 30 min before every Cocaine or Morphine injection during repeated drug administration or before Cocaine or Morphine challenge) dose-dependently attenuates the development, as well as the expression of Cocaine or Morphine locomotor sensitization. Animal model: Male Swiss mice (20-25g). Dosage: 1.25, 2.5, 5.0 mg/kg. Administration: i.p.; given 30 min prior to Cocaine (10 mg/kg) or Morphine (10 mg/kg) challenge on day 17 or 20, respectively. Result: Significantly attenuated the expression of Cocaine-induced locomotor sensitization; Attenuated the induction of Morphine-induced sensitization.
In Vitro
Preincubation of the synaptosomes with AMN082 (1 μM) for 10 min before 4-aminopyridine treatment efficiently inhibits the 4-aminopyridine-evoked release of glutamate, without altering the basal release of glutamate.

Storage & Handling

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StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Similar Products

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  • AMN082 [orb1704920]

    97.13% (May vary between batches)

    97075-46-2

    465.46

    C28H30Cl2N2

    1 mg, 5 mg, 10 mg, 25 mg
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Quick Database Links

Gene Symbol
GluR

Protocol Information

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2 mg
$ 160.00
5 mg
$ 230.00
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$ 320.00
25 mg
$ 560.00
50 mg
$ 800.00
100 mg
$ 1,240.00
200 mg
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