Amodiaquine dihydrochloride dihydrate

SKU: orb1310667

Description

Research Area

Epigenetics & Chromatin, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	6398-98-7
MW	464.82
Purity	99.97%
Formula	C₂₀H₂₈Cl₃N₃O₃
SMILES	O.Cl.CCN(CC)Cc1c(O)ccc(Nc2c3ccc(Cl)cc3ncc2)c1.O.Cl
Target	NR4A,Histone Methyltransferase,Parasite,Histamine Receptor
Solubility	H2O:27 mg/mL (58.09 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.1 mM);DMSO:85 mg/mL (182.87 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

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Target IC50

Histamine N-methyl transferase:18.6 nM(Ki)

In Vivo

In vivo administration of a small dose amodiaquine dramatically enhanced the effect of histamine on the gastric secretion in dogs. Amodiaquine prevents severe hepatic injury and high lethality in P. acnes-primed and LPS-induced hepatitis mice. Its treatment enhances the elevation of histamine in the liver of P. acnes-primed and LPS-induced hepatitis mice without accompanying tele-methyl histamine elevation.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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CXCL2, Amodiaquin, Amodiaquin dihydrochloride Dihydrate, Amodiaquin dihydrochloride dihydrate, Amodiaquine, Amodiaquine dihydrochloride dihydrate, Amodiaquine dihydrochloride Dihydrate, Amodiaquine hydrochloride, Amodiaquine Hydrochloride, antimalarial, anti-inflammatory, CCL2, HistamineReceptor, Histamine Receptor, Histone Methyltransferase, HistoneMethyltransferase, histamine N-methyl transferase, Inhibitor, Nurr1, N-methyltransferase, neuroprotective, Parasite, IL-1β, inhibit

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Compound Identifiers

PubChem CID

64646 ↗

Key Properties

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No computed properties available.

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