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ANO1-IN-1

SKU: orb1688985

Description

ANO1-IN-1 is a selective small-molecule inhibitor of ANO1 (TMEM16A) with an IC50 of 2.56 µM, showing lower potency against ANO2 (IC50 = 15.43 µM). This compound has been shown to suppress glioma cell proliferation in vitro, making it a useful research tool for studying calcium-activated chloride channels in cancer and other physiological contexts.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number407587-01-3
MW336.49
Purity99.66% (May vary between batches)
FormulaC18H28N2O2S
SMILESC(N)(=O)C=1C2=C(SC1NC(C(C)(C)C)=O)CC(C(C)(C)C)CC2
TargetChloride channel
Solubility10% DMSO+90% Saline:5 mg/mL (14.86 mM);DMSO:150 mg/mL (445.78 mM)

Bioactivity

Target IC50
ANO1:2.56 μM|ANO2:15.43 μM
In Vitro
ANO1-IN-1 (Compound 9c) (10 μM) significantly inhibits the migration and invasion of U251 cells and, in combination with TMZ, synergistically suppresses GBM cell proliferation.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ANO1, ANO2, Chloridechannel, Chloride channel

Similar Products

  • ANO1-IN-1 [orb2900831]

    >98% (HPLC)

    407587-01-3

    336.49

    C18H28N2O2S

    100 mg, 1 g, 500 mg, 5 mg, 10 mg, 25 mg, 50 mg
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Key Properties

No computed properties available.

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ANO1-IN-1 (orb1688985)

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% DMSO +
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% Tween 80 +
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Available Sizes

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5 mg
¥ 1,040.00
10 mg
¥ 1,300.00
25 mg
¥ 2,080.00
50 mg
¥ 2,990.00
100 mg
¥ 4,160.00
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