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Trastuzumab Biosimilar Antibody, Research Grade (Anti-Her2 / ErbB2)
SKU: orb348902
Featured
Description
Research Area
Signal Transduction
Images & Validation
−Item 1 of 1
| Tested Applications | ELISA, FC, IHC |
|---|---|
| Reactivity | Human |
Key Properties
−| Host | Human |
|---|---|
| Clonality | Monoclonal |
| Isotype | Human IgG |
| Clone No. | 4D5-8 (trastuzumab) |
| Immunogen | A431 cells (human epidermoid carcinoma) (over)expressing EGFR. |
| Target | erbB-2 (Her-2/neu) |
| Purity | Purified |
| Conjugation | Unconjugated |
Storage & Handling
−| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
|---|---|
| Buffer/Preservatives | PBS with 0.02% Proclin 300. |
| Concentration | 1 mg/ml |
| Expiration Date | 12 months from date of receipt. |
| Disclaimer | For research use only |
Alternative Names
−CD340; Metastatic lymph node gene 19 protein (MLN 19); Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; p185HER2; EGFR
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Trastuzumab Biosimilar Antibody, Research Grade (Anti-Her2 / ErbB2) [orb1173652]
ELISA, FC
Human
Human Humanized
Monoclonal
Unconjugated
100 μg, 50 μg
Quality Guarantee
Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].
Immunohistochemical staining of paraffin embedded human breast tissue using anti-erbB-2 antibody 4D5-8 (trastuzumab) Anti-erbB-2 (Her-2/neu) staining of paraffin embedded human breast tissue using the rabbit-chimeric version of 4D5-8 (trastuzumab) (orb348902). Antigen retreival was achieved by microwaving in citrate buffer (pH6), followed by blocking with protein block serum-free buffer. Primary antibody incubation with orb348902 was carried out at 4 µg/ml for 30 minutes. Samples were then incubated with an anti-rabbit IgG HRP secondary antibody for 20 mins followed by DAB (3, 3′-diaminobenzidine), and counter-staining with haemotoxylin. Weak membrane staining exclusively of ductal epithelial cells may be observed. Recommended concentration, 4-6 µg/ml.
Quick Database Links
Gene Symbol
erbB-2 (Her-2/neu)
UniProt
UniProt Details
− No UniProt data available
Documents Download
Datasheet
Product Information
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Protocol Information
IHC
Immunohistochemistry
FC
Flow Cytometry
ELISA
Enzyme-linked Immunosorbent Assay (EIA)
Carter, P. et al. Humanization of an anti-p185HER2 antibody for human cancer therapy Proc Natl Acad Sci U S A, 89, 4285-4289 (1992)
Trastuzumab Biosimilar Antibody, Research Grade (Anti-Her2 / ErbB2) (orb348902)
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