CD79a Antibody (PE)

SKU: orb154532

Description

Mouse monoclonal antibody conjugated to PE which recognizes CD79a that expressed in B-cells. Defects in CD79A are the cause of agammaglobulinemia type 3 (AGM3). The cytoplasmic tails of CD79A contains an ITAM (immuno-receptor tyrosine-based activation) motif, which acts to initiate the BCR signaling reactions by binding to and activating tyrosine

Research Area

Cancer, Epigenetics, Immunology, Stem Cells

Images & Validation

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Item 1 of 3

Tested Applications	FC
Reactivity	Bovine, Canine, Equine, Gallus, Guinea pig, Human, Mouse, Porcine, Primate, Rabbit, Rat
Application Notes	Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. Intracellular staining.

Key Properties

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Antibody Type	Primary Antibody
Clonality	Monoclonal
Isotype	Mouse IgG1 kappa
Clone No.	HM47
Immunogen	Synthetic peptide corresponding to C terminal amino acids 208-222 of human CD79a
Target	CD79a
Purification	Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Conjugation	PE

Storage & Handling

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Storage	Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Buffer/Preservatives	Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Disclaimer	For research use only

Alternative Names

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BCR alpha, Ig-alpha, MB-1, IGA

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Flow cytometry multicolor surface staining of human lymphocytes using anti-human CD19 (LT19) APC antibody (10 µl reagent / 100 µl of peripheral whole blood) and intracellular staining of human lymphocytes using anti-human CD79a (HM47) PE antibody (10 µl reagent / 100 µl of peripheral whole blood).

Separation of human CD79a positive B cells (red-filled) from neutrophil granulocytes (black-dashed) in flow cytometry analysis (intracellular staining) of human peripheral whole blood stained using anti-human CD79a (HM47) PE antibody (10 µl reagent / 100 µl of peripheral whole blood).

Flow cytometry intracellular staining pattern of human peripheral whole blood stained using anti-human CD79a (HM47) PE antibody (10 µl reagent / 100 µl of peripheral whole blood).

Quick Database Links

Gene Symbol

CD79a

UniProt

P11912

NCBI Gene ID

973

UniProt Details

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No UniProt data available

NCBI Gene Details

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No NCBI Gene data available

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Protocol Information

Flow Cytometry

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