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Anti-IL-6 receptor [rhPM-1 (Tocilizumab)]
SKU: orb396144
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Description
Research Area
Cancer Biology
Images & Validation
−Item 1 of 1
| Tested Applications | ELISA |
|---|---|
| Reactivity | Human |
Key Properties
−| Host | Human |
|---|---|
| Clonality | Monoclonal |
| Isotype | Human IgG |
| Clone No. | rhPM-1 (Tocilizumab) |
| Immunogen | The original antibody was generated by CDR grafting of mouse PM-1 antibody onto human REI and NEW framework regions to create rhPM-1. |
| Target | IL-6 receptor |
| Purity | Purified |
| Conjugation | Unconjugated |
Storage & Handling
−| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
|---|---|
| Buffer/Preservatives | PBS with 0.02% Proclin 300. |
| Concentration | 1 mg/ml |
| Disclaimer | For research use only |
Alternative Names
−IL6R; IL-6R; CD126; MRA; atlizumab; TCZ; Interleukin-6 receptor subunit alpha; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; IL-6R 1; Membrane glycoprotein 80; gp80; PM1; PM-1
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Immunofluorescence staining of fixed U937 cells with anti-IL-6 receptorantibody rhPM-1 (Tocilizumab). Immunofluorescence analysis of paraformaldehyde fixed U937 cells on Shi-fix™ coverslips, permeabilized with 0.15% Triton and stained with the chimeric rabbit IgG version of rhPM-1 (Tocilizumab) (orb396144) at 10 µg/ml for 1h followed by Alexa Fluor® 488 secondary antibody (1 µg/ml), showing membrane staining. The nuclear stain is DAPI (blue). Panels show from left-right, top-bottom orb396144, DAPI, merged channels and an isotype control. The isotype control was stained with an anti-Fluorescein antibody followed by Alexa Fluor® 488 secondary antibody.
Quick Database Links
Gene Symbol
IL-6 receptor
UniProt
UniProt Details
− No UniProt data available
Documents Download
Datasheet
Product Information
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Sato, K. et al. Humanization of a mouse anti-human interleukin-6 receptor antibody comparing two methods for selecting human framework regions Mol Immunol, 31, 371-381 (1994)
Anti-IL-6 receptor [rhPM-1 (Tocilizumab)] (orb396144)
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