Atipamezole hydrochloride

SKU: orb1300486

Description

Atipamezole hydrochloride is a synthetic α2-adrenergic receptor antagonist. It has been investigated in preclinical research for its potential anti-Parkinsonian effects and is commonly used in in vivo studies to reverse sedation induced by α2-agonists like medetomidine.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	104075-48-1
MW	248.75
Purity	99.74%
Formula	C₁₄H₁₆N₂·HCl
SMILES	Cl.CCC1(Cc2ccccc2C1)c1cnc[nH]1
Target	Adrenergic Receptor
Solubility	DMSO:16.67 mg/mL (67.02 mM);H2O:24.9 mg/mL (100.1 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.04 mM)

Bioactivity

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Target IC50	α2-adrenoceptor antagonist:1.6 nM（Ki）.
In Vivo	Atipamezole has been found to be well tolerated in rodents and displays only modest cardiovascular effects at dosages ranging from 0.01–1 mg/kg, administered intravenously, in anesthetized, normotensive rats. This compound is frequently utilized by veterinarians to reverse sedation or anesthesia in animals. Additionally, it has been observed to enhance sexual activity in both rats and monkeys. In situations of sustained nociception, atipamezole augments pain-related responses by inhibiting the noradrenergic feedback mechanism that normally suppresses pain. Furthermore, at low doses, atipamezole positively affects several cognitive functions in experimental animals, including alertness, selective attention, planning, learning, and recall, though its impact on short-term working memory remains unclear. Read more...
In Vitro	The affinity of atipamezole for α2-adrenoceptors and its α2/α1 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α2-adrenoceptors. It has negligible affinity for 5-HT1, 5-HT2 and I2 bindings sites. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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AdrenergicReceptor, Adrenergic Receptor, Antisedan, Atipamezole, Atipamezole Hydrochloride, Atipamezole hydrochloride, Beta Receptor, inhibit, MPV1248, MPV-1248, MPV1248 Hydrochloride, MPV-1248 hydrochloride, MPV-1248 Hydrochloride, MPV 1248, MPV 1248 Hydrochloride, Inhibitor, α2-adrenoceptor

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Compound Identifiers

PubChem CID

13649426 ↗

Key Properties

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No computed properties available.

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