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AZD-0284

SKU: orb1308615

Description

AZD-0284

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number2101291-07-8
MW524.43
Purity99.82%
FormulaC21H18F6N2O5S
SMILESCC(=O)N1Cc2cc(ccc2[C@@H]1C(=O)Nc1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(C)(=O)=O
TargetROR
Solubility10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (1.91 mM);DMSO:99 mg/mL (188.78 mM)

Bioactivity

Target IC50
RORγ:7.4( IC50
In Vitro
AZD0284 (0.37 μM; 5 days) inhibits IL-17A production in human TH17 cell , reduces polarization of TH17 into pathogenic TH17/1 cells, decrease the frequency of IL-17+ cells and double positive TH17/1 cells, and reduces IL-17A secretion and RNA expression of IL-17A, IL-17F, IL-22, and IL-23 [1.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

inhibit, Inhibitor, IL-17F, IL-17A, IL-22, L-23R, cells, AZD 0284, AZD0284, AZD-0284, RAR-related orphan receptor, tract, plaque, production, ROR, RORγ, respiratory, psoriasis, TH17, vulgaris
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

AZD-0284 (orb1308615)

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% DMSO +
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% Tween 80 +
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Available Sizes

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1 mg
¥ 1,040.00
5 mg
¥ 1,820.00
1 ml x 10 mM (in DMSO)
¥ 2,080.00
10 mg
¥ 2,470.00
25 mg
¥ 3,510.00
50 mg
¥ 4,810.00
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