Beclomethasone 17-propionate

SKU: orb1992940

Description

Beclomethasone 17-propionate is a glucocorticoid that is the active metabolite of Beclomethasone dipropionate (BDP). As a glucocorticoid receptor (GR) agonist, 17-BMP has a 13-fold higher affinity than BDP and inhibits the production of pro-inflammatory cytokines, such as CXCL8, TNF-α, and IL-6, thus exerting an anti-inflammatory effect, and it is mainly used in the treatment of asthma and allergic rhinitis.

Research Area

Metabolism Research

Images & Validation

−

Key Properties

−

CAS Number	5534-18-9
MW	464.98
Purity	98.06%
Formula	C₂₅H₃₃ClO₆
SMILES	O(C(CC)=O)[C@@]1(C(CO)=O)[C@]2(C)[C@@](C[C@@H]1C)([C@]3([C@](Cl)([C@@H](O)C2)[C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H]
Target	Drug Metabolite,Glucocorticoid Receptor
Solubility	10% DMSO+90% Corn Oil:3.3 mg/mL (7.1 mM);DMSO:100 mg/mL (215.06 mM)

Bioactivity

−

In Vitro	Beclomethasone 17-propionate has EC50 values of 0.05 nM, 0.01 nM, and 0.1 nM for IL-6, TNFα, and CXCL8, respectively.

Storage & Handling

−

Storage	store at low temperature,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

17-BMP, Beclomethasone, Beclomethasone 17 propionate, Beclomethasone 17propionate, Beclomethasone 17-propionate, Beclomethasone-17-monopropionate

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID

62965 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols