Bempedoic acid

SKU: orb1303985

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Description

Bempedoic acid (ETC1002) is an oral, once-daily small molecule that lowers LDL-C via hepatic uptake mechanisms distinct from statins, aiming to reduce associated side effects. It is utilized in cardiovascular disease research, with studies demonstrating its efficacy in both in vitro assays and in vivo models of hyperlipidemia.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	738606-46-7
MW	344.5
Purity	>98%
Formula	C₁₉H₃₆O₅
SMILES	CC(C)(CCCCCC(O)CCCCCC(C)(C)C(O)=O)C(O)=O
Target	AMPK,ATP Citrate Lyase
Solubility	Soluble in DMSO (up to at least 25 mg/ml)

Bioactivity

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In Vivo	The mechanism of action of TC-1002 primarily targets two liver enzymes: ATP-citrate lyase (ACL) and AMP-activated protein kinase (AMPK), inhibiting the synthesis of steroids and fatty acids while promoting the oxidation of mitochondrial long-chain fatty acids. ETC-1002 enhances AMPK phosphorylation levels, reduces the activity of MAPKs, and diminishes the production of pro-inflammatory cytokines and chemokines. Read more...
In Vitro	ETC-1002 is an inactivated prodrug that is transformed into its activated form, an ACL inhibitor (activated state, ETC-1002-CoA), through endogenous liver ACS activity in vivo. It inhibits the migration of leukocytes to the peritoneal cavity of mice induced by sulfatide. Additionally, ETC-1002 restores the activity of lipid AMPK and reduces the phosphorylation of JNK in diet-induced obesity mouse models, leading to a decrease in the expression of the macrophage-specific marker 4F/80. Read more...
Cell Research	Primary rat hepatocytes and differentiated human MDMs are treated with indicated concentrations of ETC-1002 for 12 h. Working solutions of ETC-1002 are prepared in serum-free RPMI 1640 containing 12 mM HEPES, 10,000 U/ml penicillin, and 100 μg/ml streptomycin. (Only for Reference) Read more...

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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ESP 55016; ETC-1002

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Compound Identifiers

PubChem CID

10472693 ↗

Key Properties

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No computed properties available.

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MW:	348.51
Formula:	C₁₉H₃₂D₄O₅

Purity:	>98% (HPLC)
CAS Number:	738606-46-7
MW:	344.4861
Formula:	C₁₉H₃₆O₅

Bempedoic acid

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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