Benzamide

SKU: orb1300473

Description

Benzamide is a benzoic acid derivative and a poly(ADP-ribose) polymerase (PARP) inhibitor. It is widely used in research to study DNA repair mechanisms, cellular stress responses, and apoptosis in both in vitro and in vivo experimental models.

Research Area

Epigenetics & Chromatin, Metabolism Research, Molecular Biology

Images & Validation

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Key Properties

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CAS Number	55-21-0
MW	121.14
Purity	99.66% (May vary between batches)
Formula	C₇H₇NO
SMILES	NC(=O)C1=CC=CC=C1
Target	PARP,Endogenous Metabolite
Solubility	DMSO:45 mg/mL (371.47 mM);Ethanol:23 mg/mL (189.86 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (16.51 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

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Target IC50	PARP:3.3 μM
In Vivo	PARP inhibitor benzamide is neuroprotective in C57Bl/6N mice against different types of neurotoxicities and without affecting body temperature. Benzamide treatment significantly decreases the iNOS expression and number of apoptotic neurons and thereby improves the neuronal survival and memory during GCI. Benzamide administration (160 mg/kg i.p.) does not induce hypothermia and reaches the CNS in 30 min in the concentration range of 0.09-0.64 mM, at which, it shows neuroprotection.
In Vitro	Benzamide, an inhibitor of PARP is protective against excitatory amino acid-induced cell death in primary cultures of neurons derived from neonatal rat brain. In addition, benzamide has more recently been shown to partially prevent the loss of dopaminergic cells and the increase in reactive gliosis caused by METH in vitro in fetal rat mesencephalic cells in culture. Benzamide prevents transformation in a cell cycle-specific manner, maximal prevention coinciding with early S phase, also characteristic of maximal susceptibility to transformation.
Cell Research	Exposure to carcinogens and benzamide is done 10 hr after the release of the metabolically induced G1/S block and exposure lasts 10 hr, followed by three washings and refeeding with fresh media. (Only for Reference)

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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EndogenousMetabolite, Inhibitor, inhibit, PARP, Methamphetamine, neuroprotective, neurotoxicity, dopamine, Endogenous Metabolite, Benzoylamide, Benzenecarboxamide, Benzamide, Amid kyseliny benzoove, Phenylamide, Phenylcarboxyamide, poly ADP ribose polymerase

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Compound Identifiers

PubChem CID

2331 ↗

Key Properties

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No computed properties available.

Protocol Information

Find More Protocols

Purity:	>98%
CAS Number:	1186222-89-8
MW:	447.5095
Formula:	C₂₃H₂₁N₅O₃S

Purity:	>98%
CAS Number:	2768088-21-5
MW:	458.43
Formula:	C₂₃H₂₁F₃N₄O₃

Purity:	>98%
CAS Number:	1646499-97-9
MW:	360.5
Formula:	C₁₈H₂₀N₂O₄S

Purity:	99.17% (May vary between batches)
CAS Number:	84225-95-6
MW:	347.24
Formula:	C₁₅H₂₀Cl₂N₂O₃

Purity:	99.50% (May vary between batches)
CAS Number:	3278-14-6
MW:	225.29
Formula:	C₁₅H₁₅NO

Benzamide

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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