Bepridil hydrochloride

SKU: orb1301830

Description

Bepridil hydrochloride is a multi-channel blocker that inhibits L-type calcium channels, the Na+/Ca2+ exchanger (NCX), sodium channels, and sarcolemmal KATP channels. It is used in cardiovascular research to study arrhythmias, ischemia-reperfusion injury, and ion channel function in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	68099-86-5
MW	403
Purity	99.45% (May vary between batches)
Formula	C₂₄H₃₅ClN₂O
SMILES	Cl.CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1
Target	Calcium Channel
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.93 mM);DMSO:130 mg/mL (322.58 mM)

Bioactivity

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In Vivo

The predominant effects of Bepridil (cumulative dose = 9.0 mg/kg i.v.) in the conscious rat were reduced coronary vascular resistance and heart rate. Bepridil showed selectivity for the coronary circulation since systemic vascular resistance was not significantly reduced until cumulative i.v. dosage of 21.0 mg/kg was administered .

In Vitro

Bepridil (1-100 microM) inhibited the K(ATP) channel current in a concentration-dependent manner. The IC(50) value of bepridil was estimated to be 10.5 microM for outward K(ATP) channel currents (holding potential, +60 mV) and 6.6 microM for inward K(ATP) channel currents (holding potential, -60 mV). Bepridil (0.1-30 microM) also inhibited K(Na) channel currents measured at the holding potential of -60 mV, in a concentration-dependent manner with an IC(50) value of 2.2 microM .

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Calcium Channel, Ca channels, Ca2+ channels, CalciumChannel, CERM-1978, CERM 1978, CERM1978, Bepridil, Bepridil hydrochloride, Bepridil Hydrochloride, Inhibitor, inhibit

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Compound Identifiers

PubChem CID

50088 ↗

Key Properties

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No computed properties available.

Protocol Information

Find More Protocols

CAS Number:	64706-54-3
MW:	366.54
Formula:	C₂₄H₃₄N₂O

Purity:	>98% (HPLC)
CAS Number:	68099-86-5
MW:	403
Formula:	C₂₄H₃₅ClN₂O

Bepridil hydrochloride

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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