Bisabolangelone

SKU: orb1297442

Description

Bisabolangelone is a bioactive small molecule with demonstrated anti-tumor, anti-inflammatory, antimicrobial, and antioxidant properties. Its mechanism involves suppressing dendritic cell activity through the inhibition of MAPK and NF-κB signaling pathways, making it a useful research tool in immunology and oncology for in vitro studies.

Research Area

Signal Transduction

Images & Validation

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Key Properties

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CAS Number	30557-81-4
MW	248.32
Purity	98.91%
Formula	C₁₅H₂₀O₃
SMILES	[H][C@]12CC(C)=CC(=O)[C@@]1([H])[C@@](C)(O)\C(O2)=C\C=C(C)C
Target	MAPK,p38 MAPK
Solubility	DMSO:25 mg/mL (100.68 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.05 mM)

Bioactivity

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In Vitro

Bisabolangelone (BISA), isolated fro the roots of Angelica koreana, has many pharmacological activities, such as anti-tumor, anti-microbial, antioxidant, and anti-inflammatory activities. BISA attenuate the production of pro-inflammatory cytokines including interleukin (IL)-12, IL-1β, and tumor necrosis factor-alpha (TNF-α), migration to macrophage inflammatory protein-3 beta, and allo-T cell activating ability of DCs. In addition, BISA affected endocytosis of DCs. Molecular studies showed that BISA suppressed MAPK phosphorylation and nuclear translocation of NF-κB p50/p65. BISA inhibited DC functions by blocking MAPK and NF-κB signalin.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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Bisabolangelone, p38MAPK, p38 MAPK, inhibit, Inhibitor, IL Receptor, MAPK, TNF-α

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Compound Identifiers

PubChem CID

10399769 ↗

Key Properties

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No computed properties available.

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