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Bivamelagon

SKU: orb1944349

Description

Bivamelagon (LB54640) is an orally active, brain-penetrant melanocortin-4 receptor (MC4R) agonist. It is a valuable research tool for investigating energy homeostasis, with applications in studies of hypothalamic obesity, diabetes, and metabolic syndrome in both in vivo and in vitro models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2641595-54-0
MW629.27
Purity100.00% (May vary between batches)
FormulaC35H53ClN4O4
SMILESC(=O)(N1[C@H](C(=O)N2CCOCC2)C[C@H](N(C(C(C)C)=O)[C@@H]3CC[C@H](C)CC3)C1)[C@H]4[C@@H](CN(C(C)(C)C)C4)C5=CC=C(Cl)C=C5
TargetMelanocortin Receptor
SolubilityDMSO:100 mg/mL (158.91 mM)

Bioactivity

Target IC50
MC4R:65 nM (Ki)
In Vivo
Bivamelagon (10-30 mg/kg, oral administration, 16 days) exhibited weight loss effects in a mouse model of obesity .
In Vitro
Bivamelagon exhibits β-arrestin recruitment activity in U2OS cells expressing MC4R and β-arrestin, with an EC₅₀ value of 4.6 nM for this activity at a duration of 90 minutes .

Storage & Handling

Storagestore under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

MelanocortinReceptor, Melanocortin Receptor, MC-4R Agonist 2

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  • Bivamelagon hydrochloride [orb1944348]

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Quality Guarantee

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Key Properties

No computed properties available.

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Bivamelagon (orb1944349)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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Available Sizes

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1 mg
¥ 4,160.00
5 mg
¥ 9,360.00
1 ml x 10 mM (in DMSO)
¥ 12,740.00
DispatchUsually dispatched over 10 weeks
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