Cart summary

You have no items in your shopping cart.

BMS-687453

SKU: orb1301718

Description

BMS-687453

Research Area

Metabolism Research, Molecular Biology

Images & Validation

Key Properties

CAS Number1000998-59-3
MW444.86
Purity99.40%
FormulaC22H21ClN2O6
SMILESCOC(=O)N(CC(O)=O)Cc1cccc(OCc2nc(oc2C)-c2ccc(Cl)cc2)c1
TargetPPAR
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.5 mM);DMSO:31 mg/mL (69.68 mM)

Bioactivity

Target IC50
PPARα (human):260 nM
In Vivo
BMS 687453 (10-100 mg/kg) reduces plasma triglyceride levels and increases HDL levels in human ApoA1 transgenic mice. It also reduces serum triglyceride and LDL levels in hamsters fed a high-fat diet
In Vitro
BMS-687453 is PPARα agonist, with an EC50 and IC50 of 10 nM and 260 nM for human PPARα and ~410-fold and more than 57-fold selectivity vs human PPARγ of 4100 nM and >15000 nM in PPAR-GAL4 transactivation assays. BMS-687453 exhibits high PPARα potency (EC50: 47 nM) with ~50-fold selectivity vs PPARγ (EC50: 2400 nM) in HepG2 cells. However, BMS-687453 shows less potent activities in rodent PPARα functional assays, with a moderate EC50 of 426 nM for mouse and 488 nM for hamster but remains a full PPARα agonist in both species .
Animal Research
Male Syrian golden hamsters were acclimated to 12 h light/dark reverse light cycle for 7 days with high fat diet, then dosed daily by oral gavage for 21 days while on the same diet. At the end of the experiment, blood samples were drawn retro-orbitally after an 18 h fast and 24 h after the last dose for the determination of serum lipid levels. Livers were dissected out for mRNA analysis .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

BMS 687453, BMS687453, BMS-687453, Inhibitor, inhibit, PPARα, PPAR, Peroxisome proliferator-activated receptors

Similar Products

  • BMS-687453 [orb1227187]

    >98% (HPLC)

    1000998-59-3

    444.9

    C22H21ClN2O6

    5 mg, 10 mg, 25 mg, 50 mg, 1 g, 500 mg, 200 mg, 2 mg, 100 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

BMS-687453 (orb1301718)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,040.00
2 mg
¥ 1,300.00
5 mg
¥ 1,690.00
1 ml x 10 mM (in DMSO)
¥ 1,820.00
10 mg
¥ 2,470.00
25 mg
¥ 4,420.00
50 mg
¥ 6,500.00
100 mg
¥ 9,490.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry