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BRD3308

SKU: orb1299101

Description

BRD3308 is a potent and selective HDAC3 inhibitor with an IC50 of 54 nM. It specifically reduces phenylephrine-induced ERK phosphorylation without affecting JNK, making it a valuable chemical probe for studying HDAC3 function in cardiac hypertrophy and fibrosis research in vitro.

Research Area

Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology, Molecular Biology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number1550053-02-5
MW287.29
Purity97.00%
FormulaC15H14FN3O2
SMILESCC(=O)Nc1ccc(cc1)C(=O)Nc1ccc(F)cc1N
TargetApoptosis,HDAC,HIV Protease
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.96 mM);DMSO:52 mg/mL (181 mM)

Bioactivity

Target IC50
HDAC3:29 nM (Ki) |HDAC3:54 nM |HDAC1:1260 nM |HDAC1:5100 nM (Ki) |HDAC2:1340 nM |HDAC2:6300 nM (Ki)
In Vivo
BRD3308 is a selective HDAC3 inhibitor,to reduce hyperglycaemia and increase insulin secretion in a rat model of type 2 diabetes. At diabetes onset, an ambulatory hyperglycaemic clamp was performed. HDAC3 inhibition improved hyperglycaemia over the study period without affecting weight gain. At the end of the hyperglycaemic clamp, circulating insulin levels were significantly higher in BRD3308-treated rats. Pancreatic insulin staining and contents were also significantly higher. These findings highlight HDAC3 as a key therapeutic target for β-cell protection in type 2 diabetes.
Animal Research
Male Zucker Diabetic Fatty (Obese) rats (6-week-old); 5 mg/kg; Intraperitoneal injection; every second day

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

β-cells, inflammatory, inhibit, Inhibitor, hyperglycaemia, Human immunodeficiency virus, insulin, HDAC, HDAC3, HIV, HIV Protease, HIVProtease, HIV-1, Histone deacetylases, latency, glucolipotoxicity, Apoptosis, diabetes, cytokines, BRD3308, BRD-3308, BRD 3308
Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

BRD3308 (orb1299101)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
¥ 1,040.00
1 ml x 10 mM (in DMSO)
¥ 1,430.00
5 mg
¥ 1,430.00
10 mg
¥ 1,820.00
25 mg
¥ 3,380.00
50 mg
¥ 5,070.00
100 mg
¥ 7,410.00
200 mg
¥ 10,530.00
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