Brepocitinib P-Tosylate

SKU: orb1309263

Description

Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent, dual JAK1 and TYK2 inhibitor with respective IC50 values of 17 nM and 23 nM. It is a research tool for investigating JAK/STAT signaling in immunological and inflammatory diseases, with applications in both in vitro cellular assays and in vivo preclinical models.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	2140301-96-6
MW	561.6
Purity	99.82%
Formula	C₂₅H₂₉F₂N₇O₄S
SMILES	Cc1ccc(cc1)S(O)(=O)=O.Cn1cc(Nc2nccc(n2)N2CC3CCC(C2)N3C(=O)[C@@H]2CC2(F)F)cn1
Target	JAK
Solubility	DMSO:23.33 mg/mL (41.54 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.56 mM)

Bioactivity

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Target IC50	JAK3:6.9 μM IC50 \|JAK1:17 nM IC50 \|JAK2:77 nM IC50
In Vivo	PF-06700841 (oral administration; for 7 consecutive days; f Male Lewis rats) treatment significantly reduces paw volume increase in a dose-dependent manne. Read more...
In Vitro	PF-06700841 has good potency against IL6/pStat1 in the CD3+ cellular subset IC50 of 81 nM), but lower Inhibition of IL6/pSTAT3, again in the CD3+ cellular subset IC50 of 641 nM). Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Brepocitinib P Tosylate, Brepocitinib PTosylate, Brepocitinib P-Tosylate, inhibit, Janus kinase, JAK3, JAK, JAK1, JAK2, Inhibitor, PF-06700841 P-Tosylate

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Compound Identifiers

PubChem CID

135087197 ↗

Key Properties

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No computed properties available.

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