Buspirone hydrochloride

SKU: orb1225273

Description

Buspirone hydrochloride is an anxiolytic psychotropic drug, is used to treat generalized anxiety disorder (GAD).(In Vitro):Buspirone hydrochloride (0-400 μg/mL; 6 hours) has cytotoxic effect in Lymphocytes. Buspirone hydrochloride (0-180 μg/mL; 0-3 hours; Lymphocytes) induces ROS formation, MMP collapse, lipid peroxidation, lysosomal damage and elevation of glutathione disulfide (GSSG).(In Vivo):Buspirone hydrochloride (1-5 mg/kg; i.p. and i.g.; for 5 days; C57BL/6N mice) reduces anxiety/depression behaviors.Buspirone hydrochloride (1-5 mg/kg; i.p. and i.g.; for 5 days; C57BL/6N mice) restores IS-shifted β-diversity in the gut microbiota.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	33386-08-2
MW	421.96
Purity	>98% (HPLC)
Formula	C₂₁H₃₂ClN₅O₂
SMILES	Cl.O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)C1=NC=CC=N1
Target	5-HT Receptor
Solubility	Ethanol: 36 mg/mL (85.31 mM); Water: 84 mg/mL (199.07 mM); DMSO: 84 mg/mL (199.07 mM)

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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MJ9022-1

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Quick Database Links

Gene Symbol

5-HT Receptor

Protocol Information

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Purity:	99.95% (May vary between batches)
CAS Number:	33386-08-2
MW:	421.96
Formula:	C₂₁H₃₂ClN₅O₂