Buspirone hydrochloride

SKU: orb1306402

Description

Buspirone hydrochloride (Buspar) is a selective serotonin 5-HT1A receptor agonist employed in the treatment of generalized anxiety disorder (GAD). It is widely used in neuroscience and pharmacology research for in vitro receptor binding assays and in vivo behavioral studies related to anxiety and serotonin signaling.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

−

Key Properties

−

CAS Number	33386-08-2
MW	421.96
Purity	99.95% (May vary between batches)
Formula	C₂₁H₃₂ClN₅O₂
SMILES	Cl.O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
Target	Dopamine Receptor\|\|\|5-HT Receptor
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.74 mM);DMSO:61.88 mg/mL (146.65 mM);H2O:42.2 mg/mL (100.01 mM)

Bioactivity

−

In Vitro

Buspirone, a clinically effective non-benzodiazepine anxiolytic drug, causes inhibition of firing of these neurons when given by intravenous (ED50 = 0.011 mg/kg, i.v.), intraperitoneal (ED50 = 0.088 mg/kg, i.p.), and intragastric (effective dose = 1.0-20.0 mg/kg, i.g.) injection. Buspirone also inhibits these cells when it is administered to the outside of recorded neurons by microiontophoresis. Buspirone is eliminated primarily by oxidative metabolism, which produces several hydroxylated metabolites, including 5-hydroxy-buspirone and 1-pyrimidinylpiperazine.

Storage & Handling

−

Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

Dopamine, Dopamine Receptor, DopamineReceptor, depression, 5HTReceptor, 5-hydroxytryptamine Receptor, 5HT Receptor, 5-HT, 5-HT1A receptor, 5-HT Receptor, anxiety, Buspar, Buspirone, Buspirone HCl, Buspirone hydrochloride, Buspirone Hydrochloride, Narol, inhibit, Inhibitor, Reactive Oxygen Species, Serotonin Receptor

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID

36431 ↗

Key Properties

−

No computed properties available.

Protocol Information

Find More Protocols

Purity:	>98% (HPLC)
CAS Number:	33386-08-2
MW:	421.96
Formula:	C₂₁H₃₂ClN₅O₂

Buspirone hydrochloride

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products