Calmidazolium chloride

SKU: orb1309880

Description

Calmidazolium chloride (R 24571) is a potent calmodulin antagonist with a Kd of 3 nM, inhibiting CaM-dependent enzymes like phosphodiesterase and Ca2+-ATPase. It is widely used in biochemical research to study calcium signaling pathways and has been shown to induce apoptosis in various cancer cell lines in vitro.

Research Area

Cell Biology, Neuroscience

Images & Validation

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Key Properties

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CAS Number	57265-65-3
MW	687.7
Purity	98.53% (May vary between batches)
Formula	C₃₁H₂₃Cl₇N₂O
SMILES	[Cl-].Clc1ccc(cc1)C(c1ccc(Cl)cc1)[n+]1ccn(CC(OCc2ccc(Cl)cc2Cl)c2ccc(Cl)cc2Cl)c1
Target	CaMK,Autophagy
Solubility	10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (4.8 mM);DMSO:240 mg/mL (348.99 mM)

Bioactivity

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Target IC50	PDE (CaM-dependent):0.15 μM\|Calmodulin:12.69 μM(mouse E14 ESCs)\|Calmodulin:3 nM(kd)\|Calmodulin:8.18 μM(mouse F9 ECCs)\|Ca2+ transporting ATPase (erythrocyte, Calmodulin-induced):0.35 μM Read more...
In Vitro	Calmidazolium chloride also induces apoptosis in certain cancer cell lines. Calmidazolium chloride (3, 5, 7, 10 μM, 30 minutes-24 hours) inhibits the growth of mouse F9 ECCs . Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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R 24571, R24571, R-24571, Inhibitor, inhibit, Calmodulin-dependent protein kinases, Calmodulin-dependent kinases, Calmodulin, calmodulin, Calmidazolium, Calmidazolium chloride, Calmidazolium Chloride, CaMK, Autophagy

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Compound Identifiers

PubChem CID

644274 ↗

Key Properties

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No computed properties available.

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