Calmidazolium chloride

SKU: orb1940814

Description

Calmidazolium chloride is a calmodulin (CaMK) antagonist (Kd = 3 nM), antagonizing CaM-dependent phosphodiesterase(IC50 = 0.15 μM) and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase(IC50 = 0.35 μM). Calmidazolium chloride also induces apoptosis in certain cancer cell lines.(In Vitro):Calmidazolium chloride inhibits growth of mouse F9 ECCs (IC50 = 8.18 μM) and E14 ESCs (IC50 = 12.69 μM).

Images & Validation

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Key Properties

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CAS Number	57265-65-3
MW	687.69
Purity	>98% (HPLC)
Formula	C₃₁H₂₃Cl₇N₂O
SMILES	[Cl-].Clc1ccc(cc1)C(c1ccc(Cl)cc1)[n+]1ccn(CC(OCc2ccc(Cl)cc2Cl)c2ccc(Cl)cc2Cl)c1
Target	CaMK
Solubility	In Vitro: DMSO : 100 mg/mL (145.41 mM)

Bioactivity

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In Vitro

Calmidazolium chloride is widely used as a calmodulin (CaM) antagonist, but is also known to induce apoptosis in certain cancer cell lines. Calmidazolium chloride (3, 5, 7, 10 μM, 30 minutes-24 hours) inhibits growth of mouse F9 ECCs. Cell Viability Assay Cell line: Mouse F9 ECCs. Concentration: 3, 5, 7, 10 μM. Incubation time: 30 minutes-24 hours. Result: The IC50s of Calmidazolium chloride treated F9 ECCs and E14 ESCs are 8.18 μM, and 12.69 μM.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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R 24571

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Gene Symbol

CaMK

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