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CB1/2 agonist 3

SKU: orb1688300

Description

CB1/2 agonist 3

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2772655-86-2
MW387.6
Purity98.78%
FormulaC25H41NO2
SMILESO=C(NC1CC1)CCCCCCCCCCOC2=CC=CC(=C2)CCCCC
TargetCannabinoid Receptor
Solubility10% DMSO+90% Corn Oil:0.5 mg/mL (1.29 mM);DMSO:8 mg/mL (20.64 mM)

Bioactivity

Target IC50
CB2-CHO cells (human):1.28 nM (EC50)|CB1-CHO cells (human):30.99 nM (EC50)|CP-55940:78.17 nM (Kb)|CB1 receptor (human):5.9 nM (Ki)|CB2 receptor (human):3.5 nM (Ki)
In Vitro
CB1/2 agonist 3 partially induce the binding of [35S]GTPγS to hCB1-CHO cell membranes with an EC5 = 0.99 nM and slightly inhibite the binding of [35S]GTPγS to hCB2-CHO cell membranes with an average EC5 = .28 nM. CB1/2 agonist 3, after treatment for 1 hour at a concentration of 1 μM , antagonize the CB1/CB2 agonist CP-55940 with K = 8.17 nM.

Storage & Handling

Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

Cannabinoid Receptor, CannabinoidReceptor, CB2, CB1
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Key Properties

No computed properties available.

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Protocol Information

CB1/2 agonist 3 (orb1688300)

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% DMSO +
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% Tween 80 +
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1 mg
¥ 1,040.00
5 mg
¥ 1,690.00
10 mg
¥ 2,340.00
25 mg
¥ 3,380.00
50 mg
¥ 4,810.00
100 mg
¥ 6,890.00
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