CB2R/FAAH modulator-3

SKU: orb1685595

Description

CB2R/FAAH modulator-3 (compound 27) is a dual-target small molecule acting as a CB2 receptor agonist (Ki=20.1 nM) and a FAAH inhibitor (IC50=3.4 µM). It shows research potential in areas including cancer, neuroinflammatory disease models, and COVID-19-related studies, as investigated in preclinical in vitro and in vivo experimental systems.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	2876918-67-9
MW	341.49
Purity	99.81%
Formula	C₂₂H₃₁NO₂
SMILES	CCCCCOc1ccccc1C(=O)NC12CC3CC(CC(C3)C1)C2
Target	FAAH,Cannabinoid Receptor
Solubility	DMSO:50 mg/mL (146.42 mM)

Bioactivity

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Target IC50	CB1:67.6 nM (Ki)\|CB2:20.1 nM (Ki)
In Vitro	CB2R/FAAH modulator-3 (compound 27) at 10 μM reduces production of the inflammatory cytokines TNFα, IFN-γ, IL-1β, and IL-6 in unstimulated monocytes and macrophages. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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FAAH, CB2R, CB2R/FAAH modulator-3, CB2R/FAAHmodulator3, Cannabinoid Receptor, CannabinoidReceptor

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Compound Identifiers

PubChem CID

166642490 ↗

Key Properties

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No computed properties available.

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