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CCI 007

SKU: orb1217450

Description

CCI 007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485

Images & Validation

Key Properties

CAS Number939228-52-1
MW336.36
Purity>98% (HPLC)
FormulaC15H16N2O5S
SMILESO=C(OCC)COC(C=CC(C=C1SC(N)=NC1=O)=C2)=C2OC
TargetHistone Demethylase
SolubilityDMSO:10 mM

Bioactivity

In Vitro
CCI-007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia. Following CCI-007 treatment for 24h, significant mitochondrial depolarization was observed in PER-485 cells as evidenced by a shift in JC-1 signal. CCI-007 alters the characteristic MLL-r gene expression signature in sensitive cells with downregulation of the expression of HOXA9, MEIS1, CMYC and BCL2.Resistance to CCI-007 can occur by upregulation of MLL target gene expression.: Cell Viability Assay Cell line: PER-485, MOLM-13, MV4; 11 cells. Concentration: 5 μM. Incubation time: 24 h. Result: Induced apoptosis.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • CCI-007 [orb1298595]

    97.81% (May vary between batches)

    939228-52-1

    336.36

    C15H16N2O5S

    1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 1 ml x 10 mM (in DMSO), 100 mg
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CCI 007 (orb1217450)

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Available Sizes

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2 mg
¥ 1,950.00
5 mg
¥ 2,730.00
10 mg
¥ 4,160.00
25 mg
¥ 7,670.00
50 mg
¥ 11,180.00
100 mg
¥ 15,730.00
500 mg
¥ 31,330.00