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CCI-007

SKU: orb1298595

Description

CCI-007 is a selective small molecule inhibitor targeting MLL-rearranged, CALM-AF10, and SET-NUP214 fusion-driven leukemias, demonstrating an IC50 of 3.5 µM in the MLL-r cell line PER-485. It serves as a valuable research tool for investigating the pathogenesis and therapeutic targeting of these aggressive leukemias in both cellular and animal models.

Research Area

Cell Biology, Epigenetics & Chromatin

Images & Validation

Key Properties

CAS Number939228-52-1
MW336.36
Purity97.81% (May vary between batches)
FormulaC15H16N2O5S
SMILESCCOC(=O)COc1ccc(\C=C2\SC(N)=NC2=O)cc1OC
TargetApoptosis,Histone Methyltransferase
Solubility10% DMSO+90% Saline:2 mg/mL (5.95 mM);DMSO:25 mg/mL (74.33 mM)

Bioactivity

In Vitro
small molecule CCI-007 was identified as a compound that selectively and significantly decreased the viability of a subset of MLL-r and related leukemia cell lines with CALM-AF10 and SET-NUP214 translocation. CCI-007 induced a rapid caspase-dependent apoptosis with mitochondrial depolarization within twenty-four hours of treatment. CCI-007 altered the characteristic MLL-r gene expression signature in sensitive cells with downregulation of the expression of HOXA9, MEIS1, CMYC and BCL2, important drivers in MLL-r leukemia, within a few hours of treatment. MLL-r leukemia cells that were resistant to the compound were characterised by significantly higher baseline gene expression levels of MEIS1 and BCL2 in comparison to CCI-007 sensitive MLL-r leukemia cells.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SET-NUP214, CMYC, CALM-AF10, CCI 007, CCI007, CCI-007, Apoptosis, inhibit, MLL-r, Inhibitor, Histone Methyltransferase, HistoneMethyltransferase, HOXA9, MEIS1

Similar Products

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    >98% (HPLC)

    939228-52-1

    336.36

    C15H16N2O5S

    2 mg, 25 mg, 100 mg, 10 mg, 1 g, 500 mg, 5 mg, 50 mg
Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

CCI-007 (orb1298595)

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Available Sizes

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1 mg
¥ 910.00
1 ml x 10 mM (in DMSO)
¥ 1,040.00
5 mg
¥ 1,430.00
10 mg
¥ 2,080.00
25 mg
¥ 3,510.00
50 mg
¥ 5,460.00
100 mg
¥ 8,580.00
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