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CHIR 98024

SKU: orb1697963

Description

CHIR 98024 is a highly potent and selective inhibitor of GSK-3α and GSK-3β, exhibiting IC50 values in the sub-nanomolar range. It is widely used in research to investigate Wnt/β-catenin signaling, neuronal function, and metabolic studies in both cellular and animal models of diseases such as diabetes and neurodegeneration.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number556813-39-9
MW486.31
Purity99.45%
FormulaC20H17Cl2N9O2
SMILESNc1nc(NCCNc2ncc(-c3ncc[nH]3)c(n2)-c2ccc(Cl)cc2Cl)ccc1[N+]([O-])=O
TargetGSK-3,S6 Kinase
SolubilityDMSO:6.88 mg/mL (14.15 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

Target IC50
GSK-3β:0.58 nM|GSK-3:0.2566 μM (EC50)|GSK-3α:0.65 nM

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CHIR-98024, CHIR 98014, CHIR 98024, CHIR98024, CHIR98014, CHIR-98014, p70 S6K, ischemic stroke, inhibit, Inhibitor, GSK-3α/β, Glycogen synthase kinase 3, Glycogen synthase kinase-3, GSK3, GSK-3, S6 Kinase, S6Kinase
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

CHIR 98024 (orb1697963)

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% DMSO +
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% Tween 80 +
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Available Sizes

Select a size below

1 mg
¥ 1,040.00
2 mg
¥ 1,170.00
1 ml x 10 mM (in DMSO)
¥ 1,820.00
5 mg
¥ 1,820.00
10 mg
¥ 2,600.00
25 mg
¥ 4,680.00
50 mg
¥ 7,280.00
100 mg
¥ 10,270.00
DispatchUsually dispatched within 3-5 working days
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