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CHIR98014

SKU: orb1223099

Description

CHIR98014, also known as CT-98024, is a reversible, cell-permeable inhibitor of GSK3α and GSK3β (IC50 = 0.65 and 0.58 nM, respectively). It is inactive against a series of other serine/threonine or tyrosine kinases. Through its effects on GSK3, CHIR98014 stimulates glycogen synthase in cells (EC50 = 106 nM), potentiates insulin-dependent glucose transport in isolated muscle strips, and improves glucose disposal in diabetic animals. CHIR98014 also reduces tau phosphorylation in rat brains and supports Wnt signaling during osteogenesis.

Images & Validation

Key Properties

CAS Number556813-39-9
MW486.31
Purity>98% (HPLC)
FormulaC20H17Cl2N9O2
SMILESc1cc(c(cc1Cl)Cl)c1nc(ncc1c1[nH]ccn1)NCCNc1nc(c(cc1)[N+](=O)[O-])N
TargetCXCR
SolubilityIn Vitro: DMSO : 125 mg/mL (257.04 mM)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CHIR98014 | CHIR-98014 | CHIR 98014

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Protocol Information

CHIR98014 (orb1223099)

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% DMSO +
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% Tween 80 +
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Available Sizes

Select a size below

200 mg
500 mg
2 mg
¥ 1,300.00
5 mg
¥ 2,080.00
10 mg
¥ 2,990.00
25 mg
¥ 5,590.00
50 mg
¥ 8,970.00
100 mg
¥ 12,740.00