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Curcumin

SKU: orb1308370

Description

Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, anti-inflammatory and antioxidant.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Infectious Disease & Virology, Molecular Biology

Customer Validated Data

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The data below is submitted by researchers worldwide. We provide this transparency to help you decide if this antibody works for your specific application or species, even if we haven't tested it ourselves.
Success by Application
Reactivity Distribution

Latest Experiments

5 Results
Dilution
Sample
Summary
Enzymatic glycosylation assay
Chemical
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Curcuma longa L. (turmeric)
For sample preparation, curcumin was dissolved...
In vitro assay
Mice
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Mice macrophage cell line (RAW264.7)
Curcumin was dissolved and used to...
In vitro assay
Mouse
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Mouse testicular cell lines (TM3 and TM4)
Curcumin was dissolved in dimethyl sulfoxide...
In vivo assay
Rat
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Sprague-Dawley rat
Curcumin was prepared by dissolving it...
In vitro assay
Human
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Human bone marrow mononuclear cells (BMMNCs)
BMMNCs were isolated from bone marrow...

Images & Validation

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Curcumin

Key Properties

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CAS Number458-37-7
MW368.38
Purity98.98%
FormulaC21H20O6
SMILESCOC1=CC(\C=C\C(=O)CC(=O)\C=C\C2=CC(OC)=C(O)C=C2)=CC=C1O
TargetHDAC,Ferroptosis,Mitophagy,Autophagy,Nrf2,Epigenetic Reader Domain,Histone Acetyltransferase,Influenza Virus
SolubilityDMSO: 265.00 mg/mL (719.37 mM), Sonication is recommended. Ethanol: 1.80 mg/mL (4.89 mM), Sonication is recommended.

Bioactivity

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Target IC50
LoVo cells viability:20 ± 0.05 µM|p300 HAT:25 μM|HCT116 cells viability:10 ± 0.03 µM
In Vivo
METHODS: To detec the anti-tumor activity in vivo Curcumin (100-200 mg/kg) was administered by gavage every three days for three weeks to C57BL/6J mice bearing mouse colon cancer tumor MC38. Results the average tumor volume and tumor weight of mice in the Curcumin treatment group were significantly reduced, an the tumor volume and tumor weight o the 200 mg/kg treatment group were also significantly lower than those o the 100 mg/kg treatment group. METHODS: To detect anti-tumor activity in vivo Curcumin (25-50 mg/kg) was injected intraperitoneally into BAL-/- mice bearing Ehrlich ascites tumor EAT once daily for ten days. Results the number of EAT cells in the peripheral tissues o the Curcumin 50 mg/kg group was significantly less than that o the tumor control group.
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In Vitro
METHODS: Retinoblastoma cells SO-Rb50 and Y79 were treated with Curcumin (10 50 μM) for 24 h. Cell viability was measured by CCK-8. Results: Curcumin dose-dependently and significantly decrease the cell viability of SO-Rb50 and Y79 cells, with IC50 of 38.4 μM and 34.8 μM, respectively METHODS: Mouse colon cancer cells MC38 were treated with Curcumin (5 50 μM) for 48 h. Apoptosis was detected by Flow Cytometry. Results: Curcumin dose-dependently induced apoptosis in MC38 cells. METHODS: Human pancreatic cancer cells PANC1 were treated with Curcumin (10-80 μg/ml) for 24 h the autophagy marker LC3 was detected by Immunofluorescence. Results the highest expression level of punctate autophagosomes was found in 40 μg mL Curcumin-treated cells.
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Cell Research
1×104 B16-R cells are cultivated as monolayer culture for 12 hr. They were then incubated in 200 μL of RPMI, 10% FBS containing curcumin at final concentration from 1–100 μM in 96-multiwell plates for 24-48 hr. After these incubations, cells are washed twice in PBS and 500 μl of fresh culture medium containing MTT (0.3 mg/mL) are added for colorimetric assay. (Only for Reference)
Read more...

Storage & Handling

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StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Diferuloylmethane, Curcumin, Autophagy, p300 histone acetylatransferase, Mitophagy, Mitochondrial Autophagy, Natural Yellow 3, Natural Yellow3, Natural Yellow-3, inhibit, Influenza Virus, InfluenzaVirus, Indian Saffron, Keap1-Nrf2, KEAP1-Nrf2, HAT, HATs, HistoneAcetyltransferase, Histone Acetyltransferase, Inhibitor, Epigenetic Reader Domain, EpigeneticReaderDomain, Ferroptosis, Turmeric yellow

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Quality Guarantee

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Compound Identifiers

PubChem CID
969516 ↗

Key Properties

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No computed properties available.

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Curcumin (orb1308370)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

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% DMSO +
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Available Sizes

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25 mg
¥ 910.00
50 mg
¥ 1,040.00
1 ml x 10 mM (in DMSO)
¥ 1,170.00
100 mg
¥ 1,170.00
500 mg
¥ 1,690.00
1 g
¥ 2,210.00
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