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CYM50260

SKU: orb1218898

Description

CYM50260 is an exquisitely agonist of sphingosine-1-phosphate 4 receptor (S1P4-R) (EC50: 45 nM). CYM50260 shows no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R.

Images & Validation

Key Properties

CAS Number1355026-60-6
MW350.6
Purity>98% (HPLC)
FormulaC14H11Cl3FNO2
SMILESFCC1=CC=C(OCCOC2=CC=C(Cl)C=C2Cl)C(Cl)=N1
TargetS1P4-R
SolubilityIn Vitro: DMSO : 125 mg/mL (356.53 mM)

Bioactivity

In Vitro
CYM50260 (Compound 22aa) is a synthetic S1P4-R agonist. CYM50260 is found 3.5-fold more potent than the hit compound (HTS-hit). CYM50260 suppresses the collagen-stimulated platelet aggregation, PDGF-AB secretion and sCD40 L release. CYM50260 reduces the release of phosphorylated-HSP27 by collagen as well as the phosphorylation of HSP27.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

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200 mg
500 mg
5 mg
$ 570.00
10 mg
$ 840.00
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$ 1,340.00
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100 mg
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