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CYM50260

SKU: orb1308416

Description

CYM50260 is a highly selective S1P4 receptor agonist with nanomolar potency, exhibiting no activity at other S1P receptor subtypes. This tool compound is valuable for investigating the specific roles of S1P4 in immune cell regulation and inflammatory processes in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1355026-60-6
MW350.6
Purity99.88% (May vary between batches)
FormulaC14H11Cl3FNO2
SMILESFCc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)n1
TargetLPL Receptor
SolubilityDMSO:50 mg/mL (142.61 mM)

Bioactivity

Target IC50
S1P4 receptor:(EC50)45 nM
In Vitro
CYM50260 is a synthetic agonist of S1P4-R. CYM50260 suppresses the collagen-stimulated platelet aggregation, sCD40L release and PDGF-AB secretion. CYM50260 is found 3.5-fold more potent than the hit compound (HTS-hit). CYM50260 decreases the release of phosphorylated-HSP27 by collagen as well as the phosphorylation of HSP27.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CYM 50260, CYM50260, CYM-50260, analysis, aggregation, Lysophospholipid Receptor, LPL, LPL Receptor, LPLReceptor, Inhibitor, inhibit, HSP27, platelet, S1P4-R, SAR, synthetic, PDGF-AB

Similar Products

  • CYM50260 [orb1218898]

    >98% (HPLC)

    1355026-60-6

    350.6

    C14H11Cl3FNO2

    10 mg, 25 mg, 50 mg, 100 mg, 1 g, 500 mg, 200 mg, 5 mg
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 90.00
5 mg
$ 160.00
1 ml x 10 mM (in DMSO)
$ 170.00
10 mg
$ 230.00
25 mg
$ 440.00
50 mg
$ 640.00
100 mg
$ 890.00
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