Cyproheptadine

SKU: orb1689449

Description

Cyproheptadine is a 5-HT2A receptor antagonist used in research to study serotonergic pathways, platelet aggregation, and thrombosis. It is applied in both in vitro binding assays and in vivo models investigating thromboembolic disease and metabolic disorders like diabetes.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	129-03-3
MW	287.4
Purity	99.92% (May vary between batches)
Formula	C₂₁H₂₁N
SMILES	C=1C=CC2=C(C1)C=CC=3C=CC=CC3C2=C4CCN(C)CC4
Target	5-HT Receptor
Solubility	DMSO:2 mg/mL (6.96 mM)

Bioactivity

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In Vivo

Cyproheptadine (1 mg/kg, intraperitoneal injection, once daily for 5 consecutive days) significantly prolonged the arterial occlusion time and tail bleeding time in C57BL/6 mice .

In Vitro

In in vitro experiments, Cyproheptadine (0.01–100 nM, 1 minute) dose-dependently inhibited serotonin-enhanced ADP-induced mouse platelet aggregation ; at a concentration of 10 nM, Cyproheptadine suppressed 15 μM serotonin-potentiated 1 μM ADP-induced platelet tyrosine phosphorylation ; Cyproheptadine also inhibited activation markers of homo sapiens platelets, including phosphatidylserine (PS) exposure (detected by annexin V), P-selectin (CD62P), and the GPIIb-IIIa complex (assessed via PAC-1 binding) .

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Quality Guarantee

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Compound Identifiers

PubChem CID

2913 ↗

Key Properties

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No computed properties available.

Protocol Information

Find More Protocols

Purity:	>99%
CAS Number:	41354-29-4
MW:	350
Formula:	C₂₁H₂₁N·HCl·1.5H₂O

Purity:	99.77% (May vary between batches)
CAS Number:	41354-29-4
MW:	341.88
Formula:	C₂₁H₂₄ClNO

Purity:	100.00% (May vary between batches)
CAS Number:	969-33-5
MW:	323.86
Formula:	C₂₁H₂₁N·HCl

Purity:	>98% (HPLC)
CAS Number:	74050-98-9
MW:	395.4268
Formula:	C₂₂H₂₂FN₃O₃

Purity:	>98% (HPLC)
CAS Number:	41354-29-4
MW:	323.86
Formula:	C₂₁H₂₂ClN

Cyproheptadine

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

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Compound Identifiers

Key Properties

Protocol Information

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