D-3263 hydrochloride

SKU: orb1709944

Description

D-3263 hydrochloride is an enteric-coated, orally bioavailable small molecule agonist of the TRPM8 (Transient Receptor Potential Melatonin 8) channel. It is utilized in research to investigate TRPM8's role in thermosensation, pain, and oncology through both in vitro cellular assays and in vivo animal studies.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	1008763-54-9
MW	409.95
Purity	99.93%
Formula	C₂₁H₃₂ClN₃O₃
SMILES	Cl.COc1ccc2n(C(=O)[C@@H]3C[C@H](C)CC[C@H]3C(C)C)c(=O)n(CCN)c2c1
Target	TRP/TRPV Channel
Solubility	DMSO:60 mg/mL (146.36 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.05 mM)

Bioactivity

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In Vitro	D-3263 hydrochloride binds and activates TRPM8, which may lead to increased entry of calcium and sodium; destruction of calcium and sodium homeostasis; induction of cell death in tumor cells expressing TRPM8. D-3263 hydrochloride may reduce the level of dihydrotestosterone (DHT), which may contribute to its inhibitory effect on prostate cancer and BPH. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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D3263 HCl, D3263 HCl salt, D3263 Hydrochloride, D-3263 Hydrochloride, D 3263 Hydrochloride, EC D-3263 HCl, TRP Channel, TRPChannel, TRPV Channel, TRPVChannel

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Compound Identifiers

PubChem CID

49787136 ↗

Key Properties

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No computed properties available.

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