D-α-Hydroxyglutaric acid disodium

SKU: orb1300436

Description

Research Area

Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	103404-90-6
MW	192.08
Purity	97.16%
Formula	C₅H₆Na₂O₅
SMILES	[Na+].[Na+].O[C@H](CCC([O-])=O)C([O-])=O
Target	ROS,Endogenous Metabolite,Reactive Oxygen Species,mTOR,ATPase
Solubility	DMSO:< 1 mg/mL (insoluble or slightly soluble);H2O:250 mg/mL (1301.54 mM)

Bioactivity

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Target IC50	α-ketoglutarate-dependent dioxygenase:0.628 mM(Ki)
In Vitro	In U-87 mg cells, D-α-Hydroxyglutaric acid disodium acts as weak antagonists of α-KG to inhibit α-KG-dependent histone demethylases and increases dimethylation on both H3K9 and H3K79. Besides, D-α-Hydroxyglutaric acid disodium inhibits ATP synthase and mTOR signaling, and thus causes growth arrest and tumor cell killing. Read more...
Cell Research	Cells are seeded in 12-well plates and, after overnight incubation, treated with the indicated concentrations of each compound. After harvesting, cells are stained with acridine orange (AO) and 4′,6-diamidino-2-phenylindole (DAPI). Cell number and viability are measured based on AO and DAPI fluorescence as measured by NC3000 following the manufacturer's instructions.(Only for Reference) Read more...

Storage & Handling

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Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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competitor, CeKDM7A, D α Hydroxyglutaric acid disodium, D-α-Hydroxyglutaric acid, DαHydroxyglutaric acid disodium, D-α-Hydroxyglutaric acid disodium, Disodium (R)-2-Hydroxyglutarate, Disodium 2-Hydroxyglutarate, D-a-Hydroxyglutaric acid, D-a-Hydroxyglutaric acid disodium, D-alpha-Hydroxyglutaric acid, D-alpha-Hydroxyglutaric acid disodium, D-alpha-Hydroxyglutaric acid disodium salt, 5-methlycytosine, ATP Synthase, inhibit, mTOR, neurotoxic, Inhibitor, IDH1, IDH2, Mammalian target of Rapamycin, H3K27me2, H3K9me2, excitotoxic, EndogenousMetabolite, Endogenous Metabolite, α-ketoglutarate, α-KG, ReactiveOxygenSpecies, Reactive Oxygen Species

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Compound Identifiers

PubChem CID

51051608 ↗

Key Properties

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No computed properties available.

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