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D18

SKU: orb1688646

Description

D18 is a dual TLR7/8 agonist (EC50: 24 nM hTLR7, 10 nM hTLR8) that epigenetically upregulates PD-L1 to potentiate anti-PD-1/PD-L1 therapy. It also serves as a cytotoxic payload for antibody-drug conjugates (ADCs), such as HE-S2, supporting research in immuno-oncology and ADC development [1].

Research Area

Cell Biology, Immunology & Inflammation

Images & Validation

Key Properties

CAS Number2230218-36-5
MW364.49
FormulaC21H28N6
SMILESN(CCCC)C=1C2=C(C=CC(CC3=CC=C(CN(C)C)C=C3)=N2)N=C(N)N1
TargetTLR,Others,PD-1/PD-L1

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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D18 (orb1688646)

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