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Dabigatran

SKU: orb1225680

Description

A reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM; an anticoagulant agent used to prevent stroke with atrial fibrillation.Thrombosis Approved(In Vitro):Dabigatran (BIBR 953) shows concentration-dependent anticoagulant effects in various species in vitro, doubling the activated partial thromboplastin time (aPTT), prothrombin time (PT) and ecarin clotting time (ECT) in human platelet-poor plasma at concentrations of 0.23, 0.83 and 0.18 μM, respectively.(In Vivo):Dabigatran (0.01-0.1 mg/kg; i.v.) inhibits clot formation with an ED50 of 0.033 mg/kg in Wessler model.

Images & Validation

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Dabigatran

Key Properties

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CAS Number211914-51-1
MW471.5111
Purity>98% (HPLC)
FormulaC25H25N7O3
SMILESCN1C2=C(C=C(C=C2)C(=O)N(CCC(=O)O)C3=CC=CC=N3)N=C1CNC4=CC=C(C=C4)C(=N)N
TargetThrombin
SolubilityDMSO: < 1 mg/mL; H2O: < 1 mg/mL

Bioactivity

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In Vivo
Dabigatran (0.01-0.1 mg/kg; i. v.) inhibits clot formation with an ED50 of 0.033 mg/kg in Wessler model. Animal model: Male rats (Wessler model). Dosage: 0.01, 0.03, 0.05 and 0.1 mg/kg. Administration: Intravenous injection. Result: Inhibited clot formation with an ED50 of 0.033 mg/kg.
In Vitro
Dabigatran (BIBR 953) shows concentration-dependent anticoagulant effects in various species in vitro, doubling the activated partial thromboplastin time (aPTT), prothrombin time (PT) and ecarin clotting time (ECT) in human platelet-poor plasma at concentrations of 0.23, 0.83 and 0.18 μM, respectively.

Storage & Handling

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StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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BIBR 953 | BIBR 953ZW | BIBR953 | BIB-953

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Quick Database Links

Gene Symbol
Thrombin

Protocol Information

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1 g
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2 mg
$ 90.00
5 mg
$ 140.00
10 mg
$ 220.00
25 mg
$ 410.00
50 mg
$ 680.00
100 mg
$ 990.00
500 mg
$ 2,060.00
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