Daporinad hydrochloride

SKU: orb1704529

Description

FK 866 hydrochloride (658084-64-1 free base)

Research Area

Cell Biology, Metabolism Research

Images & Validation

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Key Properties

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CAS Number	1785666-54-7
MW	427.97
Purity	98.99%
Formula	C₂₄H₃₀ClN₃O₂
SMILES	Cl.O=C(C=CC=1C=NC=CC1)NCCCCC2CCN(C(=O)C=3C=CC=CC3)CC2
Target	NAMPT,Apoptosis
Solubility	DMSO:10 mg/mL (23.37 mM)

Bioactivity

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In Vivo

METHODS: CB17-SCID mice injected with MM1S cells were treated with FK866 (30 mg/kg, intraperitoneal injection, twice a day, for 4 days) once a week for 3 weeks. Caliper measurements of the longest perpendicular tumor diameter were taken twice a week, and excised tumors were collected from mice for Western blot analysis to assess ERK and LC3B phosphorylation. RESULTS: A significant reduction in tumor burden was observed on day 7 of FK866 treatment, the treatment was well tolerated, without significant weight loss or neurological changes, and resulted in a significant prolongation of overall survival; tumor tissues from FK866-treated mice showed a significant reduction in ERK phosphorylation and LC3 proteolytic cleavage.

Storage & Handling

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Storage	store at low temperature \| Pure form: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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658084-64-1, 658084-64-1 free base, APO866, Apoptosis, FK866 Hydrochloride, FK-866 Hydrochloride, FK 866 hydrochloride, FK 866 hydrochloride (658084 64 1 free base), FK 866 hydrochloride (658084641 free base), FK 866 hydrochloride (658084-64-1 free base), NAMPT

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Compound Identifiers

PubChem CID

146159435 ↗

Key Properties

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No computed properties available.

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