DTL (N2) Antibody, Rabbit Polyclonal

SKU: orb67183

Description

Rabbit polyclonal to DTL.Denticleless protein homolog (DTL) belongs to the WD repeat cdt2 family. It is a substrate-specificadapter for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cyclecontrol, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also namedCRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 andCDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure propercell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or followingUV irradiation is essential to control replication licensing. In undamaged proliferating cells, theDCX(DTL) complex promotes the 'Lys-164' monoubiquitination of PCNA to regulate PCNA-dependenttranslesion DNA synthesis.

Research Area

Cancer, DNA Damage, Epigenetics

Images & Validation

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Tested Applications	WB
Dilution range	WB:1:500-1:1000
Reactivity	Human

Key Properties

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Host	Rabbit
Clonality	Polyclonal
Immunogen	N-terminal region of human DTL
Molecular Weight	79
Purity	Affinity purification
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	0.01% NaN3
Disclaimer	For research use only

Alternative Names

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anti-DTL antibody,anti-Denticleless protein homolog antibody,anti-CDT2 antibody,anti-CDW1 antibody,anti-DCAF2 antibody,anti-L2DTL antibody,anti-RAMP antibody,anti-DDB1 and CUL4associated factor 2 antibody,anti-Lethal(2) denticleless protein homolog antibody,anti-Retinoic acidregulated nuclear matrixassociated protein antibody

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Western blot analysis of total cell extracts from human Hela using DTL antibody

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UniProt

Q9NZJ0

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Protocol Information

Western Blot (IB, immunoblot)

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