(E)-2,6-Di-tertbutyl-4(4-(diethylamino)styryl)pyrylium TFA

SKU: orb2945017

Description

(E)-2,6-Di-tert-butyl-4-(4-(diethylamino)styryl)pyrylium TFA (Compound 4a) functions as a Gram-negative outer membrane permeabilizer by targeting Met47 in LptA to disrupt LptA/LptC interactions, exhibiting synergistic antibacterial activity. This compound, when in the form of (trifluoromethanesulfonate), enhances the efficacy of pol B against both wild-type and multi-drug resistant A. baumannii and E. coli strains. Additionally, (E)-2,6-Di-tert-butyl-4-(4-(diethylamino)styryl)pyrylium (trifluoromethanesulfonate) serves as an adjuvant for antibiotics combating multi-drug resistant Gram-negative bacteria.

Research Area

Infectious Disease & Virology

Images & Validation

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Key Properties

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CAS Number	2811663-45-1
MW	515.629
Formula	C₂₆H₃₆F₃NO₄S
SMILES	C(S(=O)(=O)[O-])(F)(F)F.C(=C/C1=CC=C(N(CC)CC)C=C1)\C=2C=C(C(C)(C)C)[O+]=C(C(C)(C)C)C2
Target	Antibacterial

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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Gene Symbol

Antibacterial

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