Cardamonin

SKU: orb1304760

Featured

Description

(E)-Cardamonin, also known as Alpinetin chalcone, is a natural chalconoid isolated from plants like Alpinia species. It acts as a novel and potent hTRPA1 channel antagonist (IC50 = 454 nM), making it a valuable research tool for studying pain, inflammation, and neurobiology in both in vitro and in vivo models.

Research Area

Neuroscience

Images & Validation

−

Key Properties

−

CAS Number	19309-14-9
MW	270.29
Purity	>98%
Formula	C₁₆H₁₄O₄
SMILES	C(/C=C/C1=CC=CC=C1)(=O)C2=C(OC)C=C(O)C=C2O
Target	Apoptosis,TRP/TRPV Channel
Solubility	Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 5 mg/ml).

Bioactivity

−

Target IC50	TRPA1 (human):454 nM
In Vivo	Cardamonin (3-30 mg/kg, orally administered) significantly inhibits PBQ-induced writhing. CDN also produces a significant, dose-dependent increase in the withdrawal response latencies in carrageenan-induced hyperalgesia. Read more...
In Vitro	Cardamonin selectively blocksTRPA1 activation (IC50=454 nM) while does not interact with TRPV1 nor TRPV4 channel. Docking analysis of cardamonin demonstrates a compatible interaction with A-967079-binding site of TRPA1. Cardamonin does not significantly reduce HEK293 cell viability, nor does it impair cardiomyocyte constriction. Cardamonin suppresses the expression of Tgase-2, cyclooxygenase-2 (COX-2), and p65 (nuclear factor-κB) in a concentration-dependent manner, and restores the expression of IκB in MG63 and Raw264.7 cells. Read more...
Cell Research	HEK293 cells are treated with cardamonin (0-90 μM). The cells treated in the absence of the test compound are the negative control. After incubated for 24 h, Cell Titer-Glo reagent is added to the cells and Luminescence is acquired on the plate reader. Read more...

Storage & Handling

−

Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

hTRPA1 cation channel, (E) Cardamonin, (E)-Cardamomin, (E)-Cardamoni, (E)Cardamonin, (E)-Cardamonin, (E)-Alpinetin chalcone, Alpinetin chalcone, Apoptosis, Cardamomin, Cardamoni, Cardamonin, TRPChannel, TRP Channel, TRPVChannel, TRPV Channel

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID

641785 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols

Cardamonin (orb1304760)

Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

No reviews yet

Purity:	99.78% (May vary between batches)
CAS Number:	18956-16-6
MW:	270.28
Formula:	C₁₆H₁₄O₄

CAS Number:	19309-14-9
MW:	270.28
Formula:	C₁₆H₁₄O₄

Purity:	>98% (HPLC)
CAS Number:	18956-16-6
MW:	270.28
Formula:	C₁₆H₁₄O₄

Purity:	>98% (HPLC)
CAS Number:	19309-14-9
MW:	270.28
Formula:	C₁₆H₁₄O₄

Cardamonin

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

Cardamonin [orb2567413]

(E)-Cardamonin (Standard) [orb3140759]

Cardamonin [orb2900672]

Cardamonin? [orb1225805]

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

Cardamonin (orb1304760)

Step 1: Enter information below

Step 2: Enter the in vivo formulation

Available Sizes

Email

UK Office

US Office

CN Office

Distributors