EGFRvIII Peptide TFA

SKU: orb1980013

Description

This synthetic EGFRvIII peptide, representing the tumor-specific EGFRvIII fusion junction, is presented by HLA-A*0201 and induces CD8+ T cell activation and IFN-γ production. In vivo, it enhances antitumor immunity in glioblastoma models when combined with flagellin B, increasing CD8+ T cells, reducing Tregs and tumor burden, and improving survival.

Images & Validation

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Key Properties

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MW	1079.20
Formula	C₄₈H₇₈N₁₂O₁₆.XCF₃COOH
SMILES	[H]N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](C(C)C)C(O)=O)=O)CC1=CC=C(O)C=C1)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

171361392 ↗

Key Properties

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No computed properties available.

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